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Functional and Structural Connectivity of Limbic and Interpersonally Relevant Regions in Non-suicidal Self-injury
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Functional and Structural Connectivity of Limbic and Interpersonally Relevant Regions in Non-suicidal Self-injury. |
| 개인저자 | Westlund Schreiner, Melinda. |
| 단체저자명 | University of Minnesota. Psychology. |
| 발행사항 | [S.l.]: University of Minnesota., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 131 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-06B. Dissertation Abstract International |
| ISBN | 9781392541234 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-06, Section: B.
Advisor: Klimes-Dougan, Bonnie |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Non-suicidal self-injury (NSSI) commonly begins in adolescence and is associated with an array of negative outcomes including suicide. Research has only begun to explore the neurobiological mechanisms associated with this behavior, most often among adults with borderline personality disorder. However, research is urgently needed to study NSSI among adolescents in order to understand potential neurobiological correlates. Applications of this knowledge would potentially be used to identify neurobiologically informed intervention strategies targeting these deficits and restore healthy neurodevelopmental trajectories. The present study implemented a multi-modal approach to understanding neural functioning by examining structural and functional connectivity in adolescents with versus without NSSI. Given previous clinical findings on NSSI, this study focused on brain regions implicated in negative affect and interpersonal sensitivity, the amygdala and dorsal anterior cingulate (dACC) respectively. Overall, the NSSI group showed widespread differences in both functional and structural connectivity compared to controls. These patterns were suggestive of possible influence of negative affect on emotional memory, planning of motor movements, and interpersonal relationships. Additionally, the NSSI group showed impairments in structural connectivity consistent with those seen in major depressive disorder and anxiety disorders. Given the paucity of neurobiological research on NSSI, this study represents an important first step in furthering the understanding of this behavior in adolescents and will aid in generating hypotheses for future work. |
| 일반주제명 | Clinical psychology. Neurosciences. Psychobiology. |
| 언어 | 영어 |
| 바로가기 | 
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