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The Roles of Set-9 and Set-26 in Longevity, Germline Function and RNAi Pathway
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Roles of Set-9 and Set-26 in Longevity, Germline Function and RNAi Pathway. |
| 개인저자 | Wang, Wenke. |
| 단체저자명 | Cornell University. Biology. |
| 발행사항 | [S.l.]: Cornell University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 208 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438027121 |
| 학위논문주기 | Thesis (Ph.D.)--Cornell University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Siu S. Lee. |
| 요약 | Aging, germline function and RNA interference are three distinct biological processes that associate with alterations in epigenetic state, including histone modifications. Our lab discovered two highly homologous SET domain containing genes, set |
| 요약 | My work found that SET-26 but not SET-9 plays an important role in lifespan regulation. Endogenous SET-26 is broadly expressed while SET-9 is only detectable in the germline. Specifically, somatically expressed SET-26 is implicated in lifespan d |
| 요약 | SET-9 and SET-26 are putative homologs of the human protein Mixed Lineage Leukemia 5 (hMLL5), which plays an important role in regulating hematopoietic homeostasis, cell cycle and survival. However, the molecular basis underlying hMLL5 activity |
| 일반주제명 | Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
