자료유형 | 학위논문 |
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서명/저자사항 | Vagal Mediated Heart Rate Variability and Cognitive Impairments in HIV-Seropositive Women. |
개인저자 | Nicholson, W Chance. |
단체저자명 | The University of Alabama at Birmingham. Nursing. |
발행사항 | [S.l.]: The University of Alabama at Birmingham., 2019. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
형태사항 | 190 p. |
기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
ISBN | 9781088318119 |
학위논문주기 | Thesis (Ph.D.)--The University of Alabama at Birmingham, 2019. |
일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Vance, David E. |
이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
요약 | Regardless of sufficient viral suppression, HIV exerts an ongoing inflammatory process that promotes chronic autonomic nervous system (ANS) dysfunction, accelerates physiological aging, and increases the risk of developing a spectrum of cognitive disorders (known as HIV-associated neurocognitive disorders [HAND]). Given this, identifying pathological mediators of this inflammatory response could provide insight into the mechanisms driving HAND. The vagus nerve (indexed by vagal-mediated heart rate variability [vmHRV]) could provide such a mediator as it regulates ANS activity via reciprocal cardio-neural pathways, which regulate inflammation and homeostasis. Vagal dysfunction is associated with persistent inflammatory signaling (e.g., stress or inflammatory-based disorders [such as HIV]), emotional dysregulation, and cognitive impairments. Chronically reduced vmHRV indices are observed in HIV-seropositive (SP) persons |
일반주제명 | Psychobiology. |
언어 | 영어 |
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