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Meiotic Crossover Patterning in Drosophila melanogaster
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Meiotic Crossover Patterning in Drosophila melanogaster. |
| 개인저자 | Hartmann, Michaelyn Ann. |
| 단체저자명 | The University of North Carolina at Chapel Hill. Genetics and Molecular Biology. |
| 발행사항 | [S.l.]: The University of North Carolina at Chapel Hill., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 142 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-03B. Dissertation Abstract International |
| ISBN | 9781085753234 |
| 학위논문주기 | Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Sekelsky, Jeff |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Meiosis is an essential process to halve an organism's genome in preparation for transmission to the next generation. Recombination between homologous chromosomes is necessary for the proper segregation of chromosomes, and allows the generation of genetic diversity. Mistakes in meiosis can lead to aneuploidy, therefore, to minimize mistakes, recombination is a highly regulated process. Crossovers are patterned along a chromosome, and this patterning is dictated by three phenomena known as interference, assurance, and the centromere effect. Interference assures that a crossover does not occur too close to another crossover, assurance maintains that each chromosome gets at least one crossover, and the centromere effect suppresses crossovers that occur too close to the centromere. The work detailed in this dissertation first focuses on the proteins involved in crossover formation and then investigates the regulation of the suppression of centromere-proximal crossovers. I have gained insight into a potential endonuclease, Ankle1, as well as further elucidated the role of the mei-MCM complex in creating meiotic crossovers. In addition, I discovered that centromere-proximal crossover suppression is regulated both by the highly-repetitive heterochromatin adjacent to the centromere, as well as the protein-mediated centromere effect, which extends into the euchromatin and dissipates with distance from the centromere. Overall these findings have provided insight into the mechanisms of crossover formation and patterning and provided the foundation for future studies of meiotic crossover control. |
| 일반주제명 | Genetics. Cellular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
