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Wnt/Beta-Catenin Signaling and the Tumor Microenvironment in Ewing Sarcoma Progression
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Wnt/Beta-Catenin Signaling and the Tumor Microenvironment in Ewing Sarcoma Progression. |
| 개인저자 | Hawkins, Allegra G. |
| 단체저자명 | University of Michigan. Cancer Biology. |
| 발행사항 | [S.l.]: University of Michigan., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 180 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-02B. Dissertation Abstract International |
| ISBN | 9781085671781 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
Advisor: Lawlor, Elizabeth. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Metastasis remains the primary cause of death in cancer patients. The invasion-metastasis cascade is dependent on crosstalk between tumor cells and the tumor microenvironment, including stromal cells, extracellular matrix, and blood vessels, at both primary and distal sites. Ewing sarcoma is a bone and soft tissue tumor primarily affecting children and adolescents. Patients with only local disease have high survival rates of >70%. However, current treatment strategies for patients developing metastasis have dismal survival rates of < 20%, making it imperative to better understand the biological processes that drive Ewing sarcoma metastasis. Wnt/beta-catenin activation is correlated with worse overall survival in Ewing sarcoma patients and tumor cell autonomous changes in cytoskeletal organization |
| 일반주제명 | Cellular biology. Biology. Oncology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
