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Molecular Pathways Underlying Cerebellar Abiotrophy in Arabian Horses
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Molecular Pathways Underlying Cerebellar Abiotrophy in Arabian Horses. |
| 개인저자 | Scott, Erica Yuki Azetsu. |
| 단체저자명 | University of California, Davis. Animal Biology. |
| 발행사항 | [S.l.]: University of California, Davis., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 158 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-08B(E). Dissertation Abstract International |
| ISBN | 9780355763287 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Davis, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-08(E), Section: B.
Advisers: James D. Murray |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | Cerebellar Abiotrophy is a neurodegenerative disease with an inherited component, resulting in neurodegeneration in the cerebellum. Cerebellar abiotrophy (CA) affects Arabian horses and results in an ataxic phenotype involving uncoordinated limb |
| 요약 | The uncertainty revolving around the ramifications of the CA-associated SNP on the candidate genes and crucial pathways in the cerebellum drove us to investigate the transcriptome-wide differences between healthy and CA-affected horses. Pathways |
| 요약 | Total RNA sequencing (RNA-seq) suggested differential MUTYH isoform usage in CA-affected horses. We confirmed this using more targeted approaches of quantifying mRNA expression and uncovered differential MUTYH promoter usage as well as MUTYH pro |
| 일반주제명 | Animal sciences. Animal diseases. Neurosciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
