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The Role of Protein Carbonylation in the Adipocyte Nucleus
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Role of Protein Carbonylation in the Adipocyte Nucleus. |
| 개인저자 | Hauck, Amy Katherine. |
| 단체저자명 | University of Minnesota. Biochemistry, Molecular Bio, and Biophysics. |
| 발행사항 | [S.l.]: University of Minnesota., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 169 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438170384 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: David A. Bernlohr. |
| 요약 | As the incidence of obesity rises globally, it has become increasingly imperative to identify the mechanisms that cause obesity-related metabolic disease. In particular, oxidative stress in the adipose tissue is known to cause metabolic dysfunct |
| 요약 | Protein carbonylation refers to the post-translational modification of lysine, cysteine, and histidine residues by diffusible electrophilic lipids. Specifically, 4- hydroxy-2-nonenal (4-HNE) and 4-hydroxy-2-hexenal (4-HHE) are produced at high l |
| 요약 | We found that protein carbonylation is elevated specifically in the nucleus of adipocytes as a consequence of obesity and of aging. Proteomic evaluation of these modifications revealed that the core histones and zinc finger proteins are major ta |
| 일반주제명 | Biochemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
