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Mixed Signals: Regulation of Host Metabolism by an Intracellular Bacterial Pathogen
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Mixed Signals: Regulation of Host Metabolism by an Intracellular Bacterial Pathogen. |
| 개인저자 | De Leon, Justin A. |
| 단체저자명 | University of California, Berkeley. Molecular & Cell Biology. |
| 발행사항 | [S.l.]: University of California, Berkeley., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 59 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438078444 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Berkeley, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Russell E. Vance. |
| 요약 | A hallmark of all pathogens is an ability to acquire nutrients from hosts. In order to do this, pathogens must overcome both the tight regulation of host nutrients and the host defense mechanisms deployed to protect these nutrients. |
| 요약 | In the introductory chapter of this dissertation, I begin with a discussion of innate immunity. I discuss the now appreciated view of the innate immune system as a sensor of patterns of pathogenesis. I then argue, based on our studies in Legione |
| 요약 | In chapter two, I provide experimental evidence that nutrient acquisition is a pattern of pathogenesis. I discuss my work describing how L. pneumophila alters a key metabolic signaling pathway, the mechanistic target of rapamycin complex 1 (mTOR |
| 요약 | I then close with a perspective chapter that describes the additional questions my work has given rise to and the state of the bacterial molecular pathogenicity field as a whole. |
| 일반주제명 | Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
