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Elucidation of Histone Modifications and Nucleosomal Structure Using Novel Mass Spectrometry Approaches
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Elucidation of Histone Modifications and Nucleosomal Structure Using Novel Mass Spectrometry Approaches. |
| 개인저자 | Karch, Kelly R. |
| 단체저자명 | University of Pennsylvania. Biochemistry and Molecular Biophysics. |
| 발행사항 | [S.l.]: University of Pennsylvania., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 183 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438036000 |
| 학위논문주기 | Thesis (Ph.D.)--University of Pennsylvania, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Benjamin A. Garcia |
| 요약 | The fundamental repeating unit of chromatin is the nucleosome, composed of 147 base pairs of DNA wrapped around a histone protein octamer containing two copies of H2A, H2B, H3, and H4. Histone proteins are involved in many critical nuclear proce |
| 요약 | Histone function is also mediated through its structure and dynamic properties. Hydrogen-deuterium exchange (HDX) coupled to MS is a powerful technique to monitor these properties in solution. However, traditional HDX-MS studies on histone prote |
| 일반주제명 | Biochemistry. Cellular biology. Analytical chemistry. |
| 언어 | 영어 |
| 바로가기 | 
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