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Translation Initiation During Influenza Virus Infection and Its Role in Cellular Immunity
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Translation Initiation During Influenza Virus Infection and Its Role in Cellular Immunity. |
| 개인저자 | Machkovech, Heather M. |
| 단체저자명 | University of Washington. Genome Sciences. |
| 발행사항 | [S.l.]: University of Washington., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 160 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438174382 |
| 학위논문주기 | Thesis (Ph.D.)--University of Washington, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: Jesse D. Bloom |
| 요약 | There are numerous factors that direct and constrain influenza evolution. On the one hand influenza virus is constrained to encode proteins that allow it to complete the viral life cycle, but the immune system also recognizes those same viral pr |
| 요약 | In Chapter 2, I explore one of the immune pressures that drives influenza evolution. It is well known that antibodies are a driver of the rapid evolution of influenza. However, it was unknown whether CD8 T-cells, which are also a component of ad |
| 요약 | In Chapter 3, I explore translation initiation in the context of influenza virus infection. Because CD8 T-cells shape influenza evolution and non-canonical translation initiation can generate novel CD8 T-cell epitopes, I examined whether there w |
| 일반주제명 | Virology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
