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The Human Antibody Response to DENV2 Infection and Vaccination
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Human Antibody Response to DENV2 Infection and Vaccination. |
| 개인저자 | Gallichotte, Emily Newman. |
| 단체저자명 | The University of North Carolina at Chapel Hill. Microbiology and Immunology. |
| 발행사항 | [S.l.]: The University of North Carolina at Chapel Hill., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 154 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438349414 |
| 학위논문주기 | Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Advisers: Aravinda de Silva |
| 요약 | Dengue viruses (DENVs) are mosquito-borne flaviviruses that are estimated to infect 390 million people each year. Dengue is a major global public health concern because people infected with the virus can develop dengue fever or severe dengue hem |
| 요약 | There are four antigenically distinct DENV serotypes, named DENV1 through DENV4. For my studies, I focused on DENV2 as a model to understand human protective immunity following infection or vaccination. Following natural DENV2 infections, indivi |
| 요약 | I sought to determine if DENV vaccination is able to elicit the same types of DENV2 antibodies implicated in protective immunity following natural infections. I observed that two different live DENV vaccines were able to elicit antibodies target |
| 요약 | Investigators studying DENV pathogenesis and vaccines had previously focused on the functional properties (neutralization) of human antibodies, with little consideration of the actual epitopes and mechanisms of protective immunity. Recent result |
| 일반주제명 | Virology. Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
