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From Cells to Mice: Mutations Conferring Oxidative Stress-resistance on Longevity Phenotypes in the Mouse
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | From Cells to Mice: Mutations Conferring Oxidative Stress-resistance on Longevity Phenotypes in the Mouse. |
| 개인저자 | Newell-Stamper, Breanne L. |
| 단체저자명 | University of Colorado at Boulder. Integrative Physiology. |
| 발행사항 | [S.l.]: University of Colorado at Boulder., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 139 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-02B(E). Dissertation Abstract International |
| ISBN | 9780438386150 |
| 학위논문주기 | Thesis (Ph.D.)--University of Colorado at Boulder, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Thomas E. Johnson. |
| 요약 | Oxidative stress is one of the drivers of the aging process and resistance to oxidative stress is a common characteristic of long-lived organisms. For these reasons, stress resistance has been recognized as a surrogate marker of longevity. Effor |
| 요약 | We assessed two metrics of healthspan, body weight (BW) and grip strength (GS), across the lifespan in both male and female mice. BW and GS are measures of general and neuromuscular health and are commonly assessed in mice and humans. We found t |
| 요약 | These studies are some of the few that longitudinally evaluate healthspan and lifespan in male and female mice of different genetic backgrounds. Collectively, our results show that genetic mutations conferring oxidative stress resistance slowed |
| 일반주제명 | Physiology. Genetics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
