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Determinants of the Solvent Quality of Water for Disordered Proteins

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서명/저자사항Determinants of the Solvent Quality of Water for Disordered Proteins.
개인저자Riback, Joshua A.
단체저자명The University of Chicago. Biophysical Sciences.
발행사항[S.l.]: The University of Chicago., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항135 p.
기본자료 저록Dissertation Abstracts International 80-01B(E).
Dissertation Abstract International
ISBN9780438371217
학위논문주기Thesis (Ph.D.)--The University of Chicago, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Advisers: Tobin R. Sosnick
요약How sticky are proteins? The solvent quality, or 'stickiness', of a biomolecule has significant implications for function and homeostasis, correct calibration of molecular simulations, engineering and evolution of proteins, and much more. The so
요약The demonstration that protein demixing benefits organisms is scarce yet examples of conserved demixing are common place. For example upon cellular stress, many proteins demix from the cytosol into observable foci called stress granules. In Chap
요약Based on this observation, one might expect that the unfolded state of proteins also would similarly act as if it were in a poor solvent. In Chapter 3, I demonstrate that indicate that the P domain is an outlier and that the unfolded states of m
일반주제명Biophysics.
Molecular biology.
Cellular biology.
언어영어
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