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Development of Trojan Horse Dimeric Inhibitors of P-Glycoprotein to Target HIV Reservoirs in the Brain
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Development of Trojan Horse Dimeric Inhibitors of P-Glycoprotein to Target HIV Reservoirs in the Brain. |
| 개인저자 | Agrawal, Neha. |
| 단체저자명 | Purdue University. Chemistry. |
| 발행사항 | [S.l.]: Purdue University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 210 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438361713 |
| 학위논문주기 | Thesis (Ph.D.)--Purdue University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Jean A. Chmielewski. |
| 요약 | HIV/AIDS has emerged as an incredibly serious infectious disease. The complete eradication of HIV is hindered by virus reservoir formation in the host. Some of the locations of these reservoirs include the central nervous system (CNS), resting m |
| 요약 | All the TH heterodimeric were found to inhibit P-gp mediated efflux of fluorescent substrates in T-cells as well as model blood-brain barrier cell lines. Two TH heterodimeric were found to inhibit HIV-1 replication in 12D7 cells most effectively |
| 일반주제명 | Chemistry. Organic chemistry. Biochemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
