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Neural Adaptations Following Exposure to HIV Proteins
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Neural Adaptations Following Exposure to HIV Proteins. |
| 개인저자 | Green, Matthew V. |
| 단체저자명 | University of Minnesota. Neuroscience. |
| 발행사항 | [S.l.]: University of Minnesota., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 133 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438354050 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Stanley A. Thayer. |
| 요약 | HIV associated neurocognitive disorders (HAND) affect nearly half of the population infected with HIV. Symptoms range from subclinical cognitive deficits to severe dementia which can affect daily living. The neurotoxicity produced is likely indi |
| 요약 | In this dissertation, I report viral proteins altering two types of receptors involved in regulating neuronal excitability and synaptic transmission, the excitatory NMDA receptor (NMDAR) and the inhibitory GABAAR. NMDARs initially become overact |
| 요약 | Second, I determined how the viral protein gp120 affects GABAergic inhibition. In hippocampal cultures, gp120 caused an increase in tonic GABAAR currents mediated by extrasynaptic GABAARs and an increase in the number of inhibitory synapses. Bot |
| 일반주제명 | Neurosciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
