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Cathepsin K Inhibition In Bone And Bone Marrow In Horses
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Cathepsin K Inhibition In Bone And Bone Marrow In Horses. |
| 개인저자 | Hussein, Hayam. |
| 단체저자명 | The Ohio State University. Comparative and Veterinary Medicine. |
| 발행사항 | [S.l.]: The Ohio State University., 2015. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2015. |
| 형태사항 | 181 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438051409 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2015. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Alicia Bertone. |
| 요약 | Cathepsin K (CatK), a cysteine protease, has been implicated in the process of bone resorption and inflammation. Selective inhibitors of CatK are promising therapeutic agents for the treatment of diseases associated with excessive bone loss and |
| 요약 | In the first phase of this work, we determined an optimal dose and dose interval for a CatK inhibitor (CatKI), VEL-0230, in healthy adult horses. Plasma pharmacokinetic (PK) and bone resorption biomarker [carboxy-terminal cross-linking telopepti |
| 요약 | In the second phase of this work, we evaluated bone structure and turnover in healthy young exercising horses receiving repeated oral dosing of a CatKI in a randomized, controlled, double-blinded, prospective, sufficiently powered clinical trial |
| 요약 | In the third phase of this work, we compared the effects of in vivo CatKI administration for 4 weeks to control vehicle administration for 4 weeks on equine bone marrow-derived stem and progenitor cells. Bone marrow was harvested from the stern |
| 요약 | In the fourth phase of work, we have studied two inflammatory models in equine bone marrow nucleated cells (BMNCs) |
| 일반주제명 | Cellular biology. Biomedical engineering. Biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
