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Identifying Pathogenic Stromal and Acinar Signaling for Improved Diagnosis and Treatment of Chronic Pancreatitis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Identifying Pathogenic Stromal and Acinar Signaling for Improved Diagnosis and Treatment of Chronic Pancreatitis. |
| 개인저자 | Komar, Hannah M. |
| 단체저자명 | The Ohio State University. Biomedical Sciences. |
| 발행사항 | [S.l.]: The Ohio State University., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 174 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438071476 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Gregory Lesinski |
| 요약 | Chronic pancreatitis (CP) is a devastating disease characterized by persistent inflammation and fibrosis of the pancreas leading to exocrine and endocrine insufficiency and increased risk of malignancy. Unfortunately, diagnosis of CP remains dif |
| 요약 | We hypothesized that the pro-survival Jak2/STAT3 and MAPK pathways play a role in PSC activation and proliferation and that these pathways would serve as therapeutic targets to reduce the pathogenic activity of these cells during disease. In vit |
| 요약 | To examine this hypothesis in vivo, we utilized the caerulein-induced murine model of chronic pancreatitis. Ruxolitinib was administered at 90mg/kg twice daily by oral gavage during the final week of caerulein treatment. Results show a trend tow |
| 요약 | To develop an experimental method to identify novel therapeutic and diagnostic biomarkers for CP, we hypothesized that proteomic analysis of pancreatic tissue from the caerulein-induced murine model of CP would elucidate candidate biomarkers of |
| 일반주제명 | Biomedical engineering. Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
