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Evaluating Dynamic Changes in Cancer Cell Mechanics during Epithelial to Mesenchymal Transition
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Evaluating Dynamic Changes in Cancer Cell Mechanics during Epithelial to Mesenchymal Transition. |
| 개인저자 | Volakis, Leonithas Ioannis. |
| 단체저자명 | The Ohio State University. Biomedical Engineering. |
| 발행사항 | [S.l.]: The Ohio State University., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 191 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438091528 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Samir Ghadiali. |
| 요약 | Cancer metastasis is a major cause of mortality, with Epithelial-to-Mesenchymal Transition (EMT) playing a role in facilitating increased invasion and motility. During metastasis, epithelial cells detach from the primary tumor and may acquire a |
| 요약 | Currently, there is limited information about how the tumor's mechanical and biophysical properties influence EMT and metastasis. In Chapter 2, we address these knowledge gaps. Major findings for Chapter 2 include: (1) EMT progression using TGF- |
| 요약 | Following the canonical model, TGF-beta induced EMT in pancreatic cancer cells (Panc1) and non-cancer keratinocytes (HACAT) was evaluated. Major findings for Chapter 3 include: (1) In both models biomechanical features can assess EMT progression |
| 요약 | Results from Chapters 2 and 3 suggest that altering tumor mechanics is a viable way to mitigate the initial stages of metastasis, and cell adhesion and stiffness represent the robust biomechanical features during EMT progression. Chapter 4 build |
| 일반주제명 | Biomedical engineering. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
