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Models, Mechanisms, and Treatment of Adult T-cell Leukemia/Lymphoma Bone Metastasis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Models, Mechanisms, and Treatment of Adult T-cell Leukemia/Lymphoma Bone Metastasis. |
| 개인저자 | Kohart, Nicole Ann. |
| 단체저자명 | The Ohio State University. Comparative and Veterinary Medicine. |
| 발행사항 | [S.l.]: The Ohio State University., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 221 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438098480 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Thomas Rosol. |
| 요약 | Adult T-cell Leukemia/Lymphoma (ATL) is a rapidly fatal hematological malignancy that develops in a subset of Human T-cell Leukemia Virus Type 1 (HTLV-1) carriers after a 20-40 year latency. ATL has a unique relationship to bone characterized by |
| 요약 | Several animal models exist to study the pathogenesis of HTLV-1 and ATL |
| 요약 | Elevated levels of bone acting factors PTHrP, interleukin-6 (IL-6), and macrophage inflammatory protein-1alpha (MIP-1alpha) are found in serum of patients with ATL. Studies have defined an endocrine role for these factors to act on osteoclasts a |
| 요약 | To investigate new treatments for ATL bone metastases, we selected two agents that have demonstrated success in other bone-tropic neoplasms but have not been evaluated in ATL. Histone deacetylase inhibitors (HDACi) are a class of anti-cancer age |
| 요약 | In this dissertation research, we established and characterized novel mouse models of ATL bone metastasis for preclinical and pathogenesis studies of ATL. We found several bone-acting factors expressed in ATL bone tumors, notably high PTHrP expr |
| 일반주제명 | Pathology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
