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Targeting Methylglyoxal and PPAR Gamma to Alleviate Neuropathic Pain Associated with Type 2 Diabetes
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Targeting Methylglyoxal and PPAR Gamma to Alleviate Neuropathic Pain Associated with Type 2 Diabetes. |
| 개인저자 | Griggs, Ryan B. |
| 단체저자명 | University of Kentucky. Physiology. |
| 발행사항 | [S.l.]: University of Kentucky., 2015. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2015. |
| 형태사항 | 269 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438110496 |
| 학위논문주기 | Thesis (Ph.D.)--University of Kentucky, 2015. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
|
| 요약 | Neuropathic pain affects up to 50% of the 29 million diabetic patients in the United States. Neuropathic pain in diabetes manifests as a disease of the peripheral and central nervous systems. The prevalence of type 2 diabetes is far greater than |
| 요약 | I used methodological approaches including: (1) immunohistochemical and calcium imaging to assess stimulus-evoked sensitization |
| 요약 | I hypothesized that the thiazolidinedione class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists would reduce neuropathic pain-like behavior and spinal neuron sensitization in traumatic nerve injury and type 2 diabetes. A |
| 요약 | I aimed to investigate the contribution of the glucose metabolite methylglyoxal to painful type 2 diabetes. I tested the hypothesis that methylglyoxal produces nociceptive, evoked, and affective pain that is dependent on activation of the sensor |
| 일반주제명 | Neurosciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
