상세정보
Export to Refworks부가기능
Role of TH2 Cytokines in Regulatory B Cell Biology
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Role of TH2 Cytokines in Regulatory B Cell Biology. |
| 개인저자 | Taitano, Sophina Horne. |
| 단체저자명 | University of Michigan. Immunology. |
| 발행사항 | [S.l.]: University of Michigan., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 129 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438125872 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: Nicholas W. Lukacs |
| 요약 | B cells are now appreciated to be far more than antibody secreting cells. Throughout the last two decades B cells have been described to utilize a vast array of mechanisms to influence immune responses. Immune tolerance is achieved by a network |
| 요약 | To understand how regulatory B cells are modulated during allergic responses, we investigated the effects of TH2 cytokines (IL-5 and IL-4) on their regulatory function and growth in vitro. Previously, the lab reported that culture with CD40 liga |
| 요약 | Similar in vitro cultures were performed with human B cells from the peripheral blood. Inhibitors were used to target signaling pathways downstream of CD40L and IL-5 stimulation to understand the necessary pathways for regulatory B cells growth |
| 요약 | Together this work provides insight into the modulation of regulatory B cells during allergic inflammation. We also identify possible targets to further investigate as therapeutics to enhance or inhibit regulatory B cell activity. Many protectiv |
| 일반주제명 | Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
