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Notch Ligand Delta-like 4 (Dll4) Induces Epigenetic Mechanism in Regulatory T Cell Function During Pulmonary Viral Infection
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Notch Ligand Delta-like 4 (Dll4) Induces Epigenetic Mechanism in Regulatory T Cell Function During Pulmonary Viral Infection. |
| 개인저자 | Ting, Hung-An. |
| 단체저자명 | University of Michigan. Molecular and Cellular Pathology. |
| 발행사항 | [S.l.]: University of Michigan., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 152 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438125902 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Nicholas W. Lukacs. |
| 요약 | Respiratory Syncytial Virus (RSV) infects more than 90% of children under two years of age. It is the number one leading cause of hospitalizations for infants and young children. Inpatients suffer from RSV-induced moderate to severe bronchioliti |
| 요약 | The current dissertation demonstrates that Dll4 was up-regulated by RSV infection especially on CD11b+ pulmonary dendritic cells (DC). Using systemic Dll4 neutralization and a Dll4 knockdown DC transfer model, we found that Dll4 enhanced Foxp3 e |
| 요약 | Using an epigenetic enzyme PCR array, we found that Dll4 and Notch signaling enhanced the expression of a novel histone methyltransferase-SET and MYND domain containing protein 3 (SMYD3) in vitro and in vivo during RSV infection. SMYD3 catalyze |
| 요약 | Collectively, the studies in this dissertation suggest that Notch and its ligand Dll4 augment immunomodulatory Treg cell programs to ameliorate RSV immunopathology in part through an epigenetic mechanism-SMYD3. The results presented herein lay t |
| 일반주제명 | Pathology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
