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Microfabricated Sampling Probes for Monitoring Brain Chemistry at High Spatial and Temporal Resolution

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서명/저자사항Microfabricated Sampling Probes for Monitoring Brain Chemistry at High Spatial and Temporal Resolution.
개인저자Ngernsutivorakul, Thitaphat.
단체저자명University of Michigan. Chemistry.
발행사항[S.l.]: University of Michigan., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항215 p.
기본자료 저록Dissertation Abstracts International 79-12B(E).
Dissertation Abstract International
ISBN9780438125940
학위논문주기Thesis (Ph.D.)--University of Michigan, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Robert T. Kennedy.
요약Monitoring neurochemical dynamics has played a crucial role in elucidating brain function and related disorders. An essential approach for monitoring neurochemicals is to couple sampling probes to analytical measurements
요약Conventional sampling probes were handmade and have several disadvantages, including large sizes (over 220 mum in diameter) and limited design flexibility. To address these disadvantages, we have used microfabrication to manufacture sampling pro
요약Furthermore, we have continued the development of a microfabricated push-pull probe. We enhanced functionality of the probe by integrating an additional channel into the probe for chemical delivery. Further, we demonstrated that the probe can fe
요약This collection of work illustrates that development of the microfabricated sampling probes and their compatible microfluidic systems are highly beneficial for studying brain chemistry. The integrated miniaturized analytical technology can poten
일반주제명Organic chemistry.
Neurosciences.
언어영어
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