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Epigenetic Abnormalities in Brain Tumors
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Epigenetic Abnormalities in Brain Tumors. |
| 개인저자 | Chen, Xiaoyue. |
| 단체저자명 | College of Medicine - Mayo Clinic. Biochemistry and Molecular Biology. |
| 발행사항 | [S.l.]: College of Medicine - Mayo Clinic., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 125 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438117693 |
| 학위논문주기 | Thesis (Ph.D.)--College of Medicine - Mayo Clinic, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisers: Zhiguo Zhang |
| 요약 | Epigenetics is the study of heritable changes that alters gene expression without changing DNA sequence. Previous studies showed that epigenetic alterations were associated with tumor initiation, progression and the development of chemo-resistan |
| 요약 | MGMT promoter methylation is one of the most important glioblastoma biomarkers. Hypermethylation of this promoter is associated with a lower MGMT expression and a higher efficacy of TMZ therapy. However, MGMT promoter methylation state does not |
| 요약 | Besides the development of resistance, epigenetic alterations play an important role in the initiation of DIPG. However, whether epigenetic alterations can be targeted to treat DIPG is unknown. In Chapter III, I show that inhibiting histone deme |
| 일반주제명 | Biology. Oncology. Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
