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Characterizing Heterogeneity in the Regenerative Capacity of Human Muscle Progenitor Cells
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Characterizing Heterogeneity in the Regenerative Capacity of Human Muscle Progenitor Cells. |
| 개인저자 | Riddle, Emily Suzanne. |
| 단체저자명 | Cornell University. Nutrition. |
| 발행사항 | [S.l.]: Cornell University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 174 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438344129 |
| 학위논문주기 | Thesis (Ph.D.)--Cornell University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Anna Thalacker-Mercer. |
| 요약 | Skeletal muscle regeneration following muscle damage is imperative to maintain skeletal muscle structure and function throughout the lifespan. Regeneration requires a complex series of events including activation of skeletal muscle specific stem |
| 요약 | To evaluate the age- and sex-related differences in expansion capacity of primary hMPCs, we compared markers of expansion between young and old, male and female primary hMPC cultures. hMPCs from older males have reduced expansion capacity compa |
| 요약 | Using K-means cluster analysis and measurements of culture population doubling time and saturation density, we are the first to unbiasedly cluster cultures with similar growth parameters and to identify drivers of expansion capacity that weren't |
| 요약 | Acute inflammation following muscle injury is essential to activate satellite cells. However, chronic muscle inflammation likely contributes to impaired regenerative capacity in skeletal muscle. Previous research has identified muscle inflammato |
| 요약 | This dissertation highlights the heterogeneity that exists between humans throughout the muscle regenerative process. Uncovering the molecular underpinnings of this heterogeneity is essential as the field of medicine moves towards a personalized |
| 일반주제명 | Nutrition. Physiology. Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
