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Structural Elucidation of Gas-Phase Peptide Ions by Tandem Mass Spectrometry and Molecular Dynamics Simulations
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Structural Elucidation of Gas-Phase Peptide Ions by Tandem Mass Spectrometry and Molecular Dynamics Simulations. |
| 개인저자 | Nguyen, Huong Thi Huynh. |
| 단체저자명 | University of Washington. Chemistry. |
| 발행사항 | [S.l.]: University of Washington., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 247 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438173521 |
| 학위논문주기 | Thesis (Ph.D.)--University of Washington, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Frantisek Turecek. |
| 요약 | The invention of the mass spectrometer has enabled scientists to discover numerous fascinating reactive gas-phase chemical species such as peptide cation radicals. The generation of these radicals can be accomplished via several methods includin |
| 요약 | There are several methods available for probing the conformational structures of gas-phase ions such as collision-induced dissociation (CID), ion mobility (IM), infrared multiphoton dissociation (IRMPD), and UV-Vis photodissociation (UVPD). CID |
| 요약 | In the first part of this work, which includes Chapters 2--5, the electronic structures of ETD-formed z-fragment ions were studied in detail using tandem mass spectrometry and molecular dynamics simulations. Chapter 2 investigates the photoreact |
| 요약 | In a further attempt to investigate the 3D structures of peptide ions in the gas phase, we also explored the chemistry of diazirine as a way to freeze the conformations of the ion before subjecting it to structural analysis. Diazirine has been u |
| 요약 | In part II of this work, which includes Chapter 6, the chemistry of diazirines was implemented to study non-covalent interactions of peptide complexes generated in the gas phase. Specifically, we incorporated diazirine-tagged amino acids (photol |
| 일반주제명 | Chemistry. Analytical chemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
