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Endoplasmic Reticulum Stress-Mediated Signaling in Pancreatic Cancer
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Endoplasmic Reticulum Stress-Mediated Signaling in Pancreatic Cancer. |
| 개인저자 | Dauer, Patricia. |
| 단체저자명 | University of Minnesota. Pharmacology. |
| 발행사항 | [S.l.]: University of Minnesota., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 142 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438031586 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Ashok K. Saluja. |
| 요약 | Pancreatic ductal adenocarcinoma (PDAC) ranks among the poorest prognoses for cancer patients, with an estimated 5-year survival of just 8%. The stagnant survival rates are a result of late detection, chemoresistance, and an aggressive tumor phe |
| 요약 | One promising pharmacological advancement is currently undergoing a Phase II clinical trial and has been studied by our laboratory. Triptolide is a Chinese herb, which has shown to be very effective in eliminating pancreatic cancer cells in vitr |
| 요약 | The initial study in this dissertation precipitated based on an earlier finding in the Saluja laboratory that triptolide not only downregulates heat shock protein 70 (HSP70) and specificity protein 1 (SP1), but also causes chronic endoplasmic re |
| 요약 | Even though ER stress can result in cell death, it is initially a homeostatic mechanism, which aims to protect cells. This led us to ask what role acute ER stress and UPR plays in pancreatic cancer. We show that modulating glucose regulatory pro |
| 요약 | Our investigation into acute ER stress led to further studies to characterize the UPR signaling in pancreatic cancer. We show that shGRP78 dysregulates multiple transcriptomic and proteomic pathways important in cancer (proliferation, survival, |
| 요약 | The last study in this dissertation focuses on the tumor microenvironment and SP1 oncogenic signaling. We evaluated the transcriptomic profiling conducted after treatment with triptolide revealed deregulation of the transforming growth factor be |
| 요약 | These studies underscore the importance of ER stress and understanding the complex balance of adaptation versus cell death in pancreatic cancer. We have identified SP1 and GRP78 as potential targets for future PDAC therapies. These findings have |
| 일반주제명 | Biology. Pharmacology. Cellular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
