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Breast Cancer Detection: From Tumor-specific Nanoparticles to Cell Mechanics
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Breast Cancer Detection: From Tumor-specific Nanoparticles to Cell Mechanics. |
| 개인저자 | Hu, Jingjie. |
| 단체저자명 | Princeton University. Mechanical and Aerospace Engineering. |
| 발행사항 | [S.l.]: Princeton University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 171 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438047860 |
| 학위논문주기 | Thesis (Ph.D.)--Princeton University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Winston O. Soboyejo. |
| 요약 | This thesis presents combined experimental and theoretical studies of cancer cell mechanics and peptide-enhanced nanoparticle entry/adhesion to triple negative breast cancer (TNBC) cells. |
| 요약 | The adhesive interaction between functionalized nanoparticles and biological cells is critical for effective cancer targeting. A combination of atomic force microscopy (AFM) and simulation approaches are used to evaluate the adhesion and molecul |
| 요약 | To investigate Triptorelin-MNP cluster entry mechanism and cellular uptake efficacy, thermodynamics and kinetics modeling and optical/confocal fluorescence microscopy are used to show that Triptorelin ligands enhance the uptake of Triptorelin-MN |
| 요약 | Finally, a cell mechanics approach is explored for TNBC cell detection. This involves the use of a shear assay technique, in parallel with digital image correlation and a Maxwell model for the measurements of viscoelastic properties as effective |
| 일반주제명 | Materials science. Bioengineering. Nanotechnology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
