상세정보
Export to Refworks부가기능
Characterization of the CoQ-Synthome Proteins and Binding Partners, Their Phosphorylation Status, and Alternative Splicing and Regulation in Saccharomyces cerevisiae
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Characterization of the CoQ-Synthome Proteins and Binding Partners, Their Phosphorylation Status, and Alternative Splicing and Regulation in Saccharomyces cerevisiae. |
| 개인저자 | Awad, Agape Mamdouh. |
| 단체저자명 | University of California, Los Angeles. Biochemistry & Molecular Biology 0114. |
| 발행사항 | [S.l.]: University of California, Los Angeles., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 134 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438081123 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Catherine F. Clarke. |
| 요약 | Coenzyme Q (also termed ubiquinone or Q) is an electron carrier in the mitochondrial respiratory chain that functions as an essential component in energy metabolism processes. Q transfers electrons from NADH and succinate to cytochrome c, a heme |
| 요약 | Saccharomyces cerevisiae (baker's yeast) serves as an excellent model for studies on Q because of its powerful molecular genetics and its close homology to human Q biosynthesis and function. Q biosynthesis in S. cerevisiae (which makes Q6 with s |
| 요약 | Chapter 2 investigates potential additional protein partners of the CoQ-Synthome. Via tandem affinity purification and proteomic and mass spectrometry analysis---facilitated by dualtagged Coq polypeptides---YLR290C was identified as a CoQ-Syntho |
| 요약 | Given the findings contained in Chapter 2 related to the association of Coq6 with the putative kinase of the system, Coq8, the question now remains whether Coq6 is a phosphorylated Coq polypeptide, similar to Coq3, Coq5, and Coq7. Chapter 3 furt |
| 요약 | Chapter 4 details the extensive story of alternative splicing in yeast, and in particular, as it relates to the Coenzyme Q biosynthetic pathway. Previous findings from another collaborating laboratory showed that Coq7 contained several phosphory |
| 일반주제명 | Biochemistry. Aging. Genetics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
