상세정보
Export to Refworks부가기능
Nuclear Interactions of the Rous sarcoma Virus Gag Polyprotein with the Unspliced Viral RNA
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Nuclear Interactions of the Rous sarcoma Virus Gag Polyprotein with the Unspliced Viral RNA. |
| 개인저자 | Maldonado, Rebecca Jean Ramses Kaddis. |
| 단체저자명 | The Pennsylvania State University. Cell and Molecular Biology. |
| 발행사항 | [S.l.]: The Pennsylvania State University., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 254 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438135352 |
| 학위논문주기 | Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
|
| 요약 | Retroviruses are single-stranded RNA viruses that encode viral enzymes for the reverse transcription of the RNA genome into a DNA provirus, which integrates into the host chromosome. The integrated proviral DNA is transcribed into viral RNA (vRN |
| 요약 | Gag is thought to select the unspliced gRNA for packaging. Although it was previously thought that Gag functioned solely in the cytoplasm, the Gag proteins of multiple retroviruses have recently been observed to traffic through the nucleus. Data |
| 요약 | Under steady-state conditions RSV Gag is primarily located in the cytoplasm and at the plasma membrane with a small portion of the Gag present in the nucleus. To visualize Gag: vRNA complexes in the nucleus, we created an infectious proviral con |
| 요약 | Gag.L291A preferentially co-localizes with the vRNA in the nucleus. However, a low but consistent level of co-localization exists with non-viral and nascent RNAs, suggesting a localization mechanism tied to transcription. Gag.L219A co-localizes |
| 요약 | To determine whether Gag: RNA nuclear interactions are conserved among retroviruses, we utilized a cell line that contains a stably integrated, doxycycline-inducible HIV-1 provirus that expresses HIV-1 Gag fused to GFP. The unspliced HIV-1 RNA w |
| 일반주제명 | Cellular biology. Molecular biology. Virology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
