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Chemical Synthesis and Biological Evaluation of Novel Indole-containing Heterocycles
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Chemical Synthesis and Biological Evaluation of Novel Indole-containing Heterocycles. |
| 개인저자 | Winston-Mcpherson, Gabrielle Noel. |
| 단체저자명 | The University of Wisconsin - Madison. Pharmaceutical Sciences. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 226 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438024090 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Weiping Tang. |
| 요약 | The Tang lab has developed several methodologies to generate indole containing heterocycles. These reactions are known as indole annulations. Considering that indole is present in several bioactive small molecules, we have studied the activity o |
| 요약 | Cardiovascular diseases (CVD) are one of the leading causes of death in humans world wide. Strongly associated with CVD are high low-density lipoprotein cholesterol (LDL-C) levels. This condition is known as hypercholesterolemia. Proprotein conv |
| 요약 | In partnership with Eli Lilly's Open Innovation Drug Discovery (OIDD) program, we have identified novel indole-containing heterocycles that reduce PCSK9 levels at low micromolar concentrations. Notably, our reported platinum catalyzed indole ann |
| 요약 | The aryl hydrocarbon receptor (AhR) has emerged as a target with therapeutic potential. It has been postulated that AhR may be a target for the treatment of benign prostatic hyperplasia, undesired immune response during organ transplantation, in |
| 일반주제명 | Cellular biology. Biochemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
