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Development and Applications of a Computational Method for Analyzing Biological Tubes and Cells
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Development and Applications of a Computational Method for Analyzing Biological Tubes and Cells. |
| 개인저자 | Yang, Ran. |
| 단체저자명 | Northwestern University. Interdepartmental Biological Sciences (IBiS) Graduate Program. |
| 발행사항 | [S.l.]: Northwestern University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 136 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-03B. Dissertation Abstract International |
| ISBN | 9781088319468 |
| 학위논문주기 | Thesis (Ph.D.)--Northwestern University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Carthew, Richard W. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Biological tubes are essential for animal survival, and their functions are highly dependent on tube shape. Analyzing the contributions of cell shape and organization to the morphogenesis of small tubes has been hampered by the limitations of existing programs in quantifying cell geometry on highly curved tubular surfaces and calculating tube-specific parameters. I developed a computational tool called QuBiT (Quantitative Tool for Biological Tubes) and used it to analyze morphogenesis during embryonic Drosophila trachea development. Analysis in wildtype tracheal dorsal trunks (DT) found previously unknown anterior-to-posterior gradients of cell orientation and aspect ratio as well as periodicity in the organization of cells in the main tube. Furthermore, computational modeling of tracheal expansion suggests that cell intercalation and/or rearrangement occurs but is not necessary to maintain the integrity of the DT. Analysis of tracheal mutants revealed unexpected findings, including interactions between Src42 and FoxO, Uif, and the Na+/K+ ATPase, suggesting that Src42 is a central regulator of tube size. These results demonstrate the importance of a computational tool for analyzing the morphogenesis of small diameter biological tubes and are a great asset to elucidating the biomolecular and biophysical mechanisms of tube size regulation. |
| 일반주제명 | Biology. Biochemistry. |
| 언어 | 영어 |
| 바로가기 | 
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