자료유형 | 학위논문 |
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서명/저자사항 | Nonequilibrium Nanoparticle Dynamics for the Development of Magnetic Particle Imaging. |
개인저자 | Shasha, Carolyn. |
단체저자명 | University of Washington. Physics. |
발행사항 | [S.l.]: University of Washington., 2019. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
형태사항 | 212 p. |
기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
ISBN | 9781085796880 |
학위논문주기 | Thesis (Ph.D.)--University of Washington, 2019. |
일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Krishnan, Kannan M. |
이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
요약 | Magnetic Particle Imaging (MPI) is a promising new medical imaging platform currently in the preclinical stage. MPI uses iron oxide nanoparticles as tracers, and exploits their nonlinear magnetization response to external oscillating magnetic fields. The nanoparticle response is directly measured to create an image in MPI, and so optimizing nanoparticle properties as well as external magnetic field conditions in order to obtain improved image signal is crucial to the development of MPI as a clinical platform. A deep understanding of the physics of nanoparticle relaxation is fundamental to optimization and further development of MPI.This work focuses on modeling the nonequilibrium dynamics of magnetic nanoparticles in order to optimize conditions for MPI and develop new therapeutic and diagnostic functionalities that can be integrated with MPI. A summary of theoretical models of nanoparticle dynamics is presented, and computational nonequilibrium models are outlined, which currently represent the most sophisticated methods for modeling nanoparticle dynamics. These models are verified and supported through experiment. Using these models, nanoparticle relaxation is explored in depth |
일반주제명 | Physics. Nanotechnology. Medical imaging. |
언어 | 영어 |
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