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Investigating Strategies to Enhance Microbial Production of and Tolerance Towards Aromatic Biochemicals
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Investigating Strategies to Enhance Microbial Production of and Tolerance Towards Aromatic Biochemicals. |
| 개인저자 | Machas, Michael. |
| 단체저자명 | Arizona State University. Chemical Engineering. |
| 발행사항 | [S.l.]: Arizona State University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 153 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088371787 |
| 학위논문주기 | Thesis (Ph.D.)--Arizona State University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Nielsen, David R. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Aromatic compounds have traditionally been generated via petroleum feedstocks and have wide ranging applications in a variety of fields such as cosmetics, food, plastics, and pharmaceuticals. Substantial improvements have been made to sustainably produce many aromatic chemicals from renewable sources utilizing microbes as bio-factories. By assembling and optimizing native and non-native pathways to produce natural and non-natural bioproducts, the diversity of biochemical aromatics which can be produced is constantly being improved upon. One such compound, 2-Phenylethanol (2PE), is a key molecule used in the fragrance and food industries, as well as a potential biofuel. Here, a novel, non-natural pathway was engineered in Escherichia coli and subsequently evaluated. Following strain and bioprocess optimization, accumulation of inhibitory acetate byproduct was reduced and 2PE titers approached 2 g/L - a ~2-fold increase over previously implemented pathways in E. coli. Furthermore, a recently developed mechanism toallow E. coli to consume xylose and glucose, two ubiquitous and industrially relevant microbial feedstocks, simultaneously was implemented and systematically evaluated for its effects on L-phenylalanine (Phe |
| 일반주제명 | Chemical engineering. Bioengineering. Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
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