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Diastereoselective Additions of Anhydride Enolates and Nucleophilic Alkenes to Chiral Aldehyde-derived N-Tosyl Imines
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Diastereoselective Additions of Anhydride Enolates and Nucleophilic Alkenes to Chiral Aldehyde-derived N-Tosyl Imines. |
| 개인저자 | Moore, Lucas Charles. |
| 단체저자명 | University of California, Davis. Chemistry. |
| 발행사항 | [S.l.]: University of California, Davis., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 236 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-06B. Dissertation Abstract International |
| ISBN | 9781392762523 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Davis, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-06, Section: B.
Advisor: Shaw, Jared T. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Described herein are the detailed approaches towards several synthetic organic chemistry projects. Chapter one describes the development of a new formal [4 + 2] cycloaddition reaction involving enolizable anhydrides and N-sulfonyl imines. During the course of these studies, we observed unexpected diastereoselectivity when using chiral aldehyde-derived N- sulfonyl imines. Chapter two details an investigation into this unexpected diastereoselectivity and subsequent development of a Lewis acid-mediated diastereodivergent reaction. Chapter three describes the complex synthesis of the chiral N-sulfonyl imines used as substrates in chapters one and two. Chapter four details two partially successful total synthesis efforts towards structurally related marine natural products, chrysophaentin E and colpol. Finally, chapter five describes the synthesis of three DNA gyrase inhibitors, gyramides E-F, as well as the methods used to synthesize their precursors. |
| 일반주제명 | Organic chemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
