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New Tools for Understanding and Engineering Complex Microbial Communities
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | New Tools for Understanding and Engineering Complex Microbial Communities. |
| 개인저자 | Sheth, Ravi U. |
| 단체저자명 | Columbia University. Cellular, Molecular and Biomedical Studies. |
| 발행사항 | [S.l.]: Columbia University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 356 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781392615171 |
| 학위논문주기 | Thesis (Ph.D.)--Columbia University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Wang, Harris H. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Microbes exist in unfathomably diverse, dynamic and intricately structured ecosystems. However, we lack the tools to fully capture the complexity of these microbiomes, which in turn limits our ability to understand their ecology and function. Here, I address these shortcomings by developing new high-throughput measurement tools to characterize microbiomes across functionally distinct axes. First, from a synthetic biology perspective, I leverage the bacterial CRISPR-Cas immune system to enable a new class of population-wide passive recording devices in cells for capture temporally varying signals and horizontally transferred DNA sequences. Second, in the microbiome arena, I develop a new suite of tools (experimental and theoretical) to capture and analyze the spatiotemporal dynamics of microbiomes at macroscopic and microscopic length scales. Taken together, these measurements provide deep insights into the ecology of complex microbiomes, and constitute a suite of powerful new tools to study microbes in their native context. |
| 일반주제명 | Bioengineering. Biology. Bioinformatics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
