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Immunometabolism and the Role of Complement Factor 5 in Insulin Action
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Immunometabolism and the Role of Complement Factor 5 in Insulin Action. |
| 개인저자 | Peterson, Kristin Rose. |
| 단체저자명 | Vanderbilt University. Pharmacology. |
| 발행사항 | [S.l.]: Vanderbilt University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 134 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088343203 |
| 학위논문주기 | Thesis (Ph.D.)--Vanderbilt University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Wadzinski, Brian. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Adipose tissue (AT) is a dynamic endocrine organ that contributes to metabolic health. Proper function of resident immune cells is vital to AT function, and thus the pro-inflammatory AT environment during obesity contributes to disease. Brown AT functions differently than white AT, and burns energy through thermogenesis rather than storing lipid. This Dissertation discusses what is known about immune cells in white AT, discoveries our lab has made in regards to the prevalence of immune cells in brown AT, and then focuses on a potential role for complement factor 5 (C5) in insulin action. C5 control (C5cont) and C5 deficient (C5def) mice were placed on low and high fat diets to investigate their inflammatory and metabolic phenotypes. C5def mice gained less weight while fed a high fat diet |
| 일반주제명 | Immunology. Physiology. Endocrinology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
