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Cytochrome P450 1B1 and Astrocyte Function
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Cytochrome P450 1B1 and Astrocyte Function. |
| 개인저자 | Falero Perez, Juliana M. |
| 단체저자명 | The University of Wisconsin - Madison. Molecular & Env Tox - PH. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 316 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781392399156 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Sheibani, Nader. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Cytochrome P450 1B1 (Cyp1b1) belongs to the Cytochrome P450 family of enzymes. It is expressed in extrahepatic epithelia, ocular tissues and exhibits a developmentally regulated pattern of expression. Recent studies show expression of Cyp1b1 in the neurovascular structures of the central nervous system including astrocytes (AC). Astrocytes have a prominent role in the integrity and function of the central nervous system including modulation of angiogenesis, neurogenesis and maintenance of neuroretinal function. We previously showed that Cyp1b1 expression plays a significant role in retinal vascular development and neovascularization during oxygen-induced ischemic retinopathy (OIR). We also showed that lack of Cyp1b1 expression in retinal endothelial cells and pericytes is associated with increased oxidative stress, sustained activation of NF-觀B, and up-regulation of thrombospondin-2 (TSP2 |
| 일반주제명 | Ophthalmology. Molecular biology. Toxicology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
