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Development of Parenteral Drugs for the Treatment of Seizure Emergencies

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서명/저자사항Development of Parenteral Drugs for the Treatment of Seizure Emergencies.
개인저자Vuu, Irene.
단체저자명University of Minnesota. Experimental & Clinical Pharmacology.
발행사항[S.l.]: University of Minnesota., 2019.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2019.
형태사항233 p.
기본자료 저록Dissertations Abstracts International 81-04B.
Dissertation Abstract International
ISBN9781392522974
학위논문주기Thesis (Ph.D.)--University of Minnesota, 2019.
일반주기 Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Cloyd, James C
이용제한사항This item must not be sold to any third party vendors.This item must not be added to any third party search indexes.
요약The overall objective of my dissertation is to develop alternative therapies for seizure emergencies. Status epilepticus is a condition defined as a convulsive seizure lasting more than 5 minutes and is considered a seizure emergency due to the increased risk for neuronal damage and mortality (Trinka et al. 2015). Although relatively effective, first-line therapy fails to terminate status epilepticus in 26-57% of cases, leading to increased risk of seizure refractoriness and use of second- and third-line therapies that may increase the risk of systemic complications and mortality (Treiman et al. 1998
일반주제명Pharmaceutical sciences.
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