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Mapping the Genetic Basis of Rapid Evolution to Industrial Pollutants in Atlantic Killifish (Fundulus heteroclitus)
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Mapping the Genetic Basis of Rapid Evolution to Industrial Pollutants in Atlantic Killifish (Fundulus heteroclitus). |
| 개인저자 | Miller, Jeffrey Thomas. |
| 단체저자명 | University of California, Davis. Pharmacology and Toxicology. |
| 발행사항 | [S.l.]: University of California, Davis., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 89 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781085757775 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Davis, 2018. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Whitehead, Andrew. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Multiple populations of Atlantic Killifish (Fundulus heteroclitus) that reside in heavily polluted habitats along the Atlantic coast of North America have repeatedly and rapidly evolved resistance to highly toxic dioxin-like pollutants (DLCs), which act through the aryl hydrocarbon receptor (AHR) signaling pathway. A multi-population genome-wide scan showed that wild DLC-resistant killifish populations have some shared and some unique genomic regions under selection. These studies and others suggest that resistance to the toxic effects of DLCs, such as cardiovascular and other developmental deformities, is extreme but not identical in resistant killifish populations. Here, we extended the QTL (Quantitative-Trait Locus) approach to four resistant killifish populations distributed from Massachusetts to Virginia and employed high-density QTL interval mapping to compare and contrast genetic regions associated with DLC resistance in these diverse populations. Our results show that in all four populations, a common genomic region associates with DLC resistance. This region includes two AHR pathway genes (AHR1b/2b) that did not show obvious signatures of selection in population genome scan data. Conversely, another AHR pathway gene (AIP) falls in a genomic region showing strong signatures of selection and associates with resistance in three of the four of our mapping populations. These results also suggest that variation in AHR1b/2b may have evolved by soft sweeps on standing genetic variation in resistant populations, which are difficult to detect by traditional selection scan methods. These results also suggest that AIP is an important component in the evolutionary response to complex, heavily contaminated environments. Our findings, integrated with population genomic scans for selection, reveal the unique evolutionary trajectories that led to evolved DLC resistance in wild killifish. |
| 일반주제명 | Evolution & development. Genetics. |
| 언어 | 영어 |
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