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The Role of MicroRNAs in Promoting FLT3-ITD-Induced Myeloid Malignancy
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Role of MicroRNAs in Promoting FLT3-ITD-Induced Myeloid Malignancy. |
| 개인저자 | Wallace, Jared Andrew. |
| 단체저자명 | The University of Utah. Pathology. |
| 발행사항 | [S.l.]: The University of Utah., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 88 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088311028 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Utah, 2018. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: O'Connell, Ryan. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | MicroRNA expression is dysregulated in many human cancers, including hematopoietic malignancies. Among hematopoietic malignancies, acute myeloid leukemia (AML) carries a particularly poor prognosis, leading to over 10,000 deaths each year in the US alone. The most common genetic aberration in AML is a gain-of-function mutation in the FMS-like tyrosine kinase 3 (FLT3) receptor. FLT3 internal tandem duplication (ITD) occurs in ~30% of all AML cases, and confers a negative prognosis. MicroRNA expression has been shown to be highly dysregulated in FLT3-ITD+ AML |
| 일반주제명 | Oncology. Molecular biology. Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
