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The Role of the Hippocampal-prefrontal Network in Cancer-related Cognitive Impairment: A Multimodal Cross-sectional Study
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Role of the Hippocampal-prefrontal Network in Cancer-related Cognitive Impairment: A Multimodal Cross-sectional Study. |
| 개인저자 | Apple, Alexandra Clemans. |
| 단체저자명 | Northwestern University. Clinical Psychology. |
| 발행사항 | [S.l.]: Northwestern University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 112 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088310588 |
| 학위논문주기 | Thesis (Ph.D.)--Northwestern University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Wang, Lei. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Between 30-75% of cancer patients receiving adjuvant therapy experience a decline in cognitive ability termed Cancer-Related Cognitive Impairment (CRCI). These impairments include difficulty with memory and attention, which may impact day-to-day life and work performance. Up to 35% of cancer patients continue to experience CRCI for months to years after treatment completion, suggesting a long-term cognitive deficiency. Developing quantitative methods to detect the neural correlates of CRCI, and treatments to mitigate its symptoms will be imperative to improve cancer patients' quality of life. However, such advances will require a better understanding of the neural mechanisms underlying CRCI. Studies of CRCI have demonstrated objective cognitive impairments on neuropsychological exams in patients following cancer treatment. The most frequently impaired cognitive domains include memory, executive functioning, processing speed, and attention. Chemotherapy, hormone therapy and other cancer treatments are thought to impair cognitive functioning by altering specific brain structures and/or impairing functional connectivity between brain regions. The hippocampus and prefrontal cortex (PFC) are known to be integrally involved in memory and executive functioning, and are particularly sensitive to the effects of such treatments. Moreover, structural and functional imaging studies suggest that adjuvant cancer therapies target the structure of brain hub regions within in resting state networks, as well as overall resting state connectivity integrity. Despite evidence of cognitive decline and structural and functional changes in cancer patients, the precise mechanism of impairment is poorly understood. The current collection of analysis revealed shape deformation on the surface of the hippocampus as well as decreases in cortical thickness in the left PFC. Bilateral hippocampal-cortical functional connectivity was increased in patients compared to controls. Increased hippocampal-precuneus functional connectivity was associated with worse perceived cognitive abilities. This work sheds light on possible neural compensation as well as biomarkers of self-reported cognitive concern in CRCI. |
| 일반주제명 | Neurosciences. Psychology. Oncology. |
| 언어 | 영어 |
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